How to Manage Polycythemia Caused by Testosterone Replacement Therapy

TRT
March 8, 2022
Fact-checked by Dr. Avidon Appel

Introduction

This article will discuss the possible risks of polycythemia caused by testosterone replacement therapy, and how to manage it. Read on to learn more about the condition, its symptoms, and its connection to testosterone replacement therapy.

What is Polycythemia?

Polycythemia is a medical condition in which there is an increase in the number of red blood cells in your blood. This may cause the blood to be thicker than normal. Polycythemia can lead to health problems such as an increased risk of heart attack or stroke.

Causes of Polycythemia

Polycythemia may be caused by a variety of factors, including:1. Testosterone replacement therapy2. Genetic disorders3. Smoking4. Obesity5. Chronic diseases such as heart or kidney disease6. Cancer7. Radiation therapy8. Certain medications, such as chemotherapy drugs9. Steroid use

Symptoms of Polycythemia

Symptoms of polycythemia can include the following:• Headache• Dizziness• Neck pain• Chest pain• Shortness of breath• Weakness• Fatigue• Prolonged bleeding time• Swelling of the hands and feet• Reddish-brown urineIf you are experiencing any of these symptoms, it is important to see your doctor right away. Left untreated, polycythemia can lead to serious health problems.

Managing Polycythemia

If you are diagnosed with polycythemia, your doctor will likely recommend treatment to manage the condition. Treatments may include:1. Taking blood-thinning medications such as aspirin or warfarin (Coumadin)2. Restricting your activity level3. Receiving a phlebotomy, which is a procedure that removes blood from your body4. Taking medications to lower your red blood cell count, such as hydroxyurea (Droxia, Hydrea) or anagrelide (Agrylin)5. Receiving radiation therapy on your head and neck6. Undergoing a bone marrow transplant7. Having surgery to remove your spleen8. Taking testosterone replacement therapy (TRT)If you are taking TRT and are diagnosed with polycythemia, your doctor may recommend stopping TRT and/or exploring any of the aforementioned treatment options.Managing polycythemia can be a challenge, but with proper treatment you can live a healthy life. Talk to your doctor if you have any questions or concerns.

Polycythemia Prevention

There are a few ways to help prevent polycythemia from developing while on testosterone replacement therapy:1. Maintain a Healthy Weight – being overweight can increase the risk of polycythemia2. Drink Plenty of Fluids – staying hydrated will prevent the build-up of red blood cells3. Get Regular Exercise – exercise keeps the body healthy and can lower your risk of experiencing polycythemia4. Avoid Tobacco Smoke – smoking increases the risk of polycythemia5. Follow Your Doctor’s Instructions – listen to your doctor’s recommendations and follow their instructions closely

Conclusion

Polycythemia can be a serious medical condition, but it can be managed with proper treatment. If you are taking testosterone replacement therapy and are diagnosed with polycythemia, your doctor may recommend stopping TRT and/or exploring some of the treatment options listed above. If you find that you're experiencing any of the symptoms of polycythemia while taking TRT, visit a doctor as soon as possible.


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March 8, 2022

Written By
Jake Peter

Fact-checked By
Dr. Avidon Appel

Editorial Process
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About Author

Dr. Avidon Appel is the founder of Iron Mountain Men’s Health. He is an Internal Medicine Specialist based in Willow Grove, PA who specializes in men’s sexual health and hormone optimization and has over 19 years of experience in the medical field. He is a graduate of Philadelphia College of Osteopathic Medicine, as well as Saint Joseph’s University.

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