Does Semaglutide Make You Tired?

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Written By Jake Peter
Dr. Avidon Appel
April 29, 2024
Fact-checked by Dr. Avidon Appel

In recent years, semaglutide has emerged as an effective option for those seeking to lose weight. However, as the medication has grown more popular, some users have reported experiencing fatigue.

In this article, we'll discuss the relationship between semaglutide and fatigue and provide insights into what you can expect when starting this medication.

What Are the Side Effects of Semaglutide for Weight Loss?

Like all medications, semaglutide carries side effects. When used for weight loss, the side effects of semaglutide can include:

  • Nausea

  • Vomiting

  • Diarrhea

  • Constipation

  • Fatigue

  • Headaches

  • Dizziness

In addition to the aforementioned effects, there are more rare but severe side effects associated with semaglutide that should not be overlooked. These include:

  • Pancreatitis

  • Kidney damage

  • Gallbladder problems

  • Serious allergic reactions

  • Thyroid tumors

Why Am I So Tired on Semaglutide?

Feeling tired while using semaglutide for weight loss is not uncommon. This sensation of fatigue can be attributed to changes in your metabolism and a decrease in your caloric intake as semaglutide works to dampen your appetite.

Furthermore, semaglutide can cause other side effects, such as nausea and digestive issues, which could further impact your energy levels. While using this medication, it's important to monitor your health and consult your doctor if you experience any severe or long-lasting side effects.

How Long Does Semaglutide Fatigue Last?

The duration of semaglutide fatigue can vary among users, but it generally lasts for about two to six weeks. Fortunately, for most patients, this tiredness diminishes as their body adjusts to the medication.

If your fatigue persists beyond the aforementioned timeframe or becomes particularly bothersome, be sure to consult your doctor.

Does Semaglutide Affect Sleep?

Emerging evidence suggests a complex relationship between semaglutide and sleep. While formal research specifically addressing how semaglutide influences sleep is limited, some individuals using the medication have reported both positive and negative changes in their sleep quality.

Side effects of semaglutide, like nausea or constipation, may negatively impact some users' sleep. Ultimately, though, more research is needed to fully understand the impact of semaglutide on sleep.

Does Semaglutide Give You Energy?

Semaglutide may not directly boost your energy levels, but the weight loss and improved metabolic health you may achieve with it can lead to more energy. For instance, weight loss often improves sleep quality and reduces one's risk of sleep apnea, which can result in better rest and more energy during the day.

Additionally, improved insulin sensitivity and blood sugar levels can yield more stable energy levels and minimize the peaks and troughs that contribute to fatigue.

How Do You Beat Semaglutide Fatigue?

If you experience fatigue while using semaglutide, the following strategies can help:

  • Stay Hydrated: Dehydration can exacerbate fatigue. Ensure you're drinking enough water throughout the day to combat tiredness.

  • Maintain a Balanced Diet: Consuming a diet rich in fruits, vegetables, whole grains, and lean proteins can provide sustained energy. Avoiding large meals and opting for smaller, more frequent meals can also help.

  • Regular Exercise: While it may seem counterintuitive, engaging in regular physical activity can actually boost energy levels. Even light exercises like walking can be beneficial.

  • Adequate Sleep: Ensuring you get a good night's sleep is crucial to managing fatigue. Aim for seven to nine hours of quality sleep per night.

  • Manage Stress: High stress levels can lead to exhaustion. Techniques such as meditation, yoga, and deep-breathing exercises can help you lower your stress.

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April 29, 2024

Written By
Dr. Avidon Appel

Fact-checked By
Dr. Avidon Appel

Editorial Process
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About Author

Dr. Avidon Appel is the founder of Iron Mountain Men’s Health. He is an Internal Medicine Specialist based in Willow Grove, PA who specializes in men’s sexual health and hormone optimization and has over 19 years of experience in the medical field. He is a graduate of Philadelphia College of Osteopathic Medicine, as well as Saint Joseph’s University.

Jake Peter
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